IMMUNE MEMORY INDUCTION BY PLATINUM BASED COMPOUNDS

• Main Authors: Aniruddha SENGUPTA, Sanghamitra MYLAVARAPU, Monideepa ROY, Shiladitya SENGUPTA
• Format: Patent
• Language: English; Spanish
• Published: 19.09.2019
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS; SUGARS

The present invention pertains to a method of treating cancer or its relapse in mammals by employing platinum based compounds. More particularly, the present invention provides to enhance immunity in a mammal, using a compound of Formula I and/or Formula II, preferably Compound 1 or its derivative, salt, tautomeric form, isomer, polymorph, solvate, or intermediates thereof. The method of inducing an immune response in a mammal is mediated through immune memory. The present invention also provides for such platinum based compounds and their use in treating cancer, metastasis or cancer relapse. La presente invención se refiere a un método para tratar el cáncer o su recidiva en mamíferos mediante el uso de compuestos basados en platino. Más particularmente, la presente invención proporciona una mejora para la inmunidad en un mamífero, usando un compuesto de Fórmula I y/o Fórmula II, preferiblemente el Compuesto 1 o su derivado, sal, forma tautomérica, isómero, polimorfo, solvato o productos intermedios de los mismos. El método de inducir una respuesta inmune en un mamífero es mediado a través de la memoria inmune. La presente invención también proporciona dichos compuestos basados en platino y su uso en el tratamiento del cáncer, la metástasis o la recidiva del cáncer.