ENGINEERED TRAIL FOR CANCER THERAPY

Engineered single chain trail molecules are provided, as are particular mutations and combinations of mutations that improve the stability and manufacturability of such molecules. These molecules are provided for use as anti-cancer therapeutics. La presente invención se refiere a moléculas TRAIL de...

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Bibliographic Details
Main Authors Eric M. TAM, Birgit M. SCHOEBERL, Diana Hung-yi Chai MARCANTONIO, Stephen L. SAZINSKY
Format Patent
LanguageEnglish
Spanish
Published 10.01.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Engineered single chain trail molecules are provided, as are particular mutations and combinations of mutations that improve the stability and manufacturability of such molecules. These molecules are provided for use as anti-cancer therapeutics. La presente invención se refiere a moléculas TRAIL de cadena sencilla diseñadas por ingeniería genética, como son mutaciones y combinaciones de mutaciones particulares que mejoran la estabilidad y manufacturabilidad de tales moléculas. Estas moléculas se proporcionan para uso como terapéuticos anti-cancerígenos.
Bibliography:Application Number: MX20180011219