TREATMENT OF TUMORS INCORPORATING MUTANT ISOCITRATE DEHYDROGENASE

• Main Authors: Yaguang SI, Marie C. KEENAN
• Format: Patent
• Language: English; Spanish
• Published: 20.02.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with a DHODH inhibitor or an antimetabolite. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by a DHODH inhibitor or an antimetabolite, comprising assessing whether the tumor cell comprises a mutant IDH gene or protein whereby cells that comprise a mutant IDH gene or protein are sensitive to inhibition by DHODH inhibitors and antimetabolites. La presente invención proporciona métodos de diagnóstico y pronóstico para predecir la efectividad de tratamiento de un paciente con cáncer con un inhibidor de DHODH o un antimetabolito; se proporcionan métodos para predecir la sensibilidad de crecimiento de células tumorales a la inhibición por medio del inhibidor de DHODH o un antimetabolito, que comprende evaluar si la célula tumoral comprende un gen IDH mutante o proteína, por lo cual las células que comprenden un gen IDH mutante o proteína son sensibles a la inhibición por medio de inhibidores DHODH y antimetabolitos.