PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1, 2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLI DINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF

The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e ]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumat...

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Main Authors Michael J. ROZEMA, Ahmed A. OTHMAN, Ahmad Y. SHEIKH, Lakshmi BHAGAVATULA, Peter T. MAYER, Lars F. NORDSTROEM, Patrick J. MARROUM, Thomas B. BORCHARDT, Mohamed- Eslam F. MOHAMED, Jayanthy JAYANTH, Mathew M. MULHERN, Ayman D. ALLIAN
Format Patent
LanguageEnglish
Spanish
Published 29.11.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e ]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process. La presente descripción se refiere a procesos para la preparación de (3S,4R)-3-etil-4-(3H-imidazo-[1,2-a]-pirrolo-[2,3-e]-pirazin-8- il)-N-(2,2, 2-trifluoro-etil)-pirrolidin-1-carboxamid a, a las formas en estado sólido de la misma, y a las composiciones farmacéuticas correspondientes, a los métodos de tratamiento (incluyendo el tratamiento de artritis reumatoide), kits, métodos de síntesis, y subproductos del proceso.
Bibliography:Application Number: MX20180004605