HETEROARYL DERIVATIVES AS PARP INHIBITORS

• Main Authors: Nishant Ramniwasji GUPTA, Sanjay Pralhad KURHADE, Ganesh Rajaram JADHAV, Venkata P. PALLE, Neelima SINHA, Navnath Popat KARCHE, Ajay Ramchandra TILEKAR, Rajender Kumar KAMBOJ
• Format: Patent
• Language: English; Spanish
• Published: 28.05.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein ring Ar, ring B, R1-R5, X, Y, p, q, r, and s are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject. Se dan a conocer compuestos de fórmula (I), sus formas tautoméricas, estereoisómeros y sales farmacéuticamente aceptables de los mismos,(ver formula) en la que el anillo Ar, el anillo B, R1-R5, X, Y, p, q, r y s son tal como se definen en la memoria descriptiva, composiciones farmacéuticas que incluyen un compuesto, tautómero, estereoisómero o sal del mismo, y métodos de tratamiento o prevención de enfermedades o trastornos, por ejemplo, cáncer, que son sensibles a tratamiento o prevención mediante inhibición de la enzima PARP de un sujeto.