PIPERAZINE DERIVATIVE

• Main Authors: Norio ASAI, Takuya MAKINO, Kyoichi MAENO, Daisuke TANABE, Hiroyuki MORITOMO, Yasuhiro YONETOKU, Hisashi MIHARA, Kazuhiko OSODA, Naomi HOSOGAI, Takashi SUGANE, Keizo SUGASAWA, Daisuke YAMASHITA, Takafumi SHIMIZU
• Format: Patent
• Language: English; Spanish
• Published: 24.04.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

[Problem] To provide a compound that can be used as an MC4 receptor agonist. [Solution] The inventors studied MC4 receptor agonists, confirmed that a piperazine derivative has an action, and perfected the present invention. Specifically, this piperazine derivative has an MC4 receptor agonist action and can be used as an agent for the prevention and/or treatment of bladder and urinary tract diseases, especially underactive bladder, hypotonic bladder, noncontracting bladder, detrusor muscle hypoactivity, neurogenic bladder, urethral relaxation failure, detrusor-external sphincter incoordination, and dysuria in benign prostatic hyperplasia. Problema Proporcionar un compuesto que se pueda usar como agonista del receptor MC4. Medio para solucionarlo Los presentes inventores han investigado agonistas del receptor MC4 y han encontrado que un derivado de piperazina tiene acción relacionada con los agonistas, con lo cual se completa la presente invención. Es decir que el derivado de piperazina de la presente invención tiene acción agonista del receptor MC4 y se puede usar como agente para prevenir y/o tratar enfermedades de la vejiga y/o el tracto urinario, en particular, vejiga hipoactiva, vejiga hipotónica, vejiga acontráctil, hipoactividad del detrusor, vejiga neurogénica, falla de la relajación uretral, disinergia detrusor-esfínter uretral externo e hiperpiasia prostática benigna.