PROCESS FOR PREPARING (E)-(5,6-DIHYDRO-1,4,2-DIOXAZINE-3-YL) (2-HYDROXYPHENYL) METHANONE O-METHYL OXIME
A process for preparing (E)-(5,6-dihydro-l,4,2-dioxazin-3-yl)(2- hydroxyphenyl)methanone O-methyl oxime is described which includes: (i) reacting benzofuran-3(2H)-one O-methyl oxime (1) with at least one nitrite selected from n-butyl nitrite and tert-butyl nitrite, in the presence of a metal alkoxid...
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Main Authors | , , , , , , , , , |
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Format | Patent |
Language | English Spanish |
Published |
04.05.2018
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Subjects | |
Online Access | Get full text |
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Summary: | A process for preparing (E)-(5,6-dihydro-l,4,2-dioxazin-3-yl)(2- hydroxyphenyl)methanone O-methyl oxime is described which includes: (i) reacting benzofuran-3(2H)-one O-methyl oxime (1) with at least one nitrite selected from n-butyl nitrite and tert-butyl nitrite, in the presence of a metal alkoxide to form (2Z,32)-2,3-benzofuran-dione O3-methyl dioxime (2) as the predominant isomer; (ii) reacting the (2Z,3Z)-2,3-benzofuran-dione O -methyl dioxime (2) with 2- haloethanol to form (2Z,3Z)-benzofuran-2,3-dione 02-(2-hydroxyethyl) O3 -methyl dioxime (3); and (iii) reacting the (2Z,3Z)-benzofuran-2,3-dione 02-(2-hydroxyethyl) & -methyl dioxime (3) with an acid to form (E)-(5,6-dihydro-l,4,2-dioxazin-3-yl)(2- hydroxyphenyl)methanone (9-methyl oxime (4);.
Se describe un proceso para preparar O-metil oxima de (E)-(5,6-dihidro-1,4,2-dioxazin-3-il)(2-hidroxifenil)metanona que incluye: (i) hacer reaccionar Ometil oxima de benzofuran-3(2H)-ona (1) con al menos un nitrito seleccionado entre nitrito de n-butilo y nitrito de terc-butilo, en presencia de un alcóxido metálico para formar O3-metil dioxima de (2Z,3Z)-2,3-benzofuran-diona (2) como isómero predominante; (ii) hacer reaccionar la O-metil dioxima de (2Z,3Z)-2,3-benzofuran-dion a (2) con 2-haloetanol para formar O2-(2-hidroxietil) O3-metil dioxima de (2Z,3Z)-benzofuran-2,3-diona (3); y (iii) hacer reaccionar la O2-(2-hidroxietil) O3-metil dioxima de (2Z,3Z)-benzofuran-2,3-diona (3) con un ácido para formar O-metil oxima de (E)-(5,6-dihidro-1,4,2-dioxazin-3-il)(2-hidroxifenil)meta nona (4);. |
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Bibliography: | Application Number: MX20170015326 |