METHODS AND COMPOSITIONS FOR TREATING A SUBJECT WITH A SMAD7 ANTISENSE OLIGONUCLEOTIDE

• Main Author: MONTELEONE, Giovanni
• Format: Patent
• Language: English; Spanish
• Published: 07.12.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis) using antisense nucleotides that are directed against polymorphic forms (e.g., those containing single nucleotide polymorphisms) of the SMAD7 mRNA. The invention thus relates to treatment methods for subjects having polymorphic forms of SMAD7 and antisense oligonucleotides that specifically target SMAD7 mRNA transcripts containing polymorphisms. La presente invención se refiere al tratamiento de una enfermedad intestinal inflamatoria (por ejemplo, enfermedad de Crohn y colitis ulcerativa) utilizando nucleótidos antisentido que se dirigen contra formas polimórficas (por ejemplo, aquellas que contienen polimorfismos de de nucleótidos sencillos) del ARNm SMAD7; así, la invención se refiere a métodos de tratamiento para sujetos que tienen formas polimórficas de SMAD7 y oligloneuclótidos antisentido que hacen objetivo específicamente transcripciones de ARNm SMAD7 que contienen polimorfismos.