PROSTATE CANCER CLASSIFICATION

• Main Authors: Laura HILL, Andrena MCCAVIGAN, Timothy DAVISON, Paul HARKIN, Steven WALKER, Richard KENNEDY
• Format: Patent
• Language: English; Spanish
• Published: 13.10.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

A method is provided for characterising and/or prognosing prostate cancer in a subject comprising determining the expression level of at least one of CREM, ERRFI1, SRSF5, PDK4, HJURP, PDRG1, TRPM3, PDE4D, F12, ADAMTS1, ADAMTS9, B3GNT5, CD38, CEBPD, CENPF, DKK1, EMP1, F3, IL1 R1, IL8, JUNB, KLF10, KLF4, LDLR, LGALS3, LPAR1, MALAT1, MTUS1, MYBPC1, NFIL3, NR4A3, OAT, PI15, PTGS2, RHOBTB3, RIN2, RNFT2, SELE, SLC15A2, SOCS2, SOCS3, SSTR1, ST6GAL1, TSC22D1, XBP1 and ZFP36 in a sample from the subject. The method may be used to predict the likelihood of metastasis. Also disclosed are methods for diagnosing and selecting treatment for prostate cancer, together with corresponding methods of treatment. Systems, kits and computer programs for performing the methods are also provided. Se proporciona un método para la caracterización y/o pronóstico de cáncer de próstata en un individuo, que consiste en: determinar el nivel de expresión de al menos uno de los siguientes CREM, ERRFI1, SRSF5, PDK4, HJURP, PDRG1, TRPM3, PDE4D, F12, ADAMTS1, ADAMTS9, B3GNT5, CD38, CEBPD, CENPF, DKK1, EMP1, F3, IL1 R1, IL8, JUNB, KLF10, KLF4, LDLR, LGALS3, LPAR1, MALAT1, MTUS1, MYBPC1, NFIL3, NR4A3, OAT, PI15, PTGS2, RHOBTB3, RIN2, RNFT2, SELE, SLC15A2, SOCS2, SOCS3, SSTR1, ST6GAL1, TSC22D1, XBP1 y ZFP36 en una muestra obtenida del individuo. El método puede utilizarse para predecir la probabilidad de metástasis. También se describen los métodos para el diagnóstico y selección del tratamiento para cáncer de próstata, junto con los métodos de tratamiento correspondientes. También se proporcionan sistemas, kits y programas de cómputo para realizar los métodos.