FORM 2 CRYSTALLINE POLYMORPH OF A SALT OF N-[1-6-(ETHYNYL-3-OXO-H EXAHYDRO-FURO[3,2-B]PYRROLE-4-CARBONYL)-3-METHYL-BUTYL]-4-[5-FLU ORO-2-(4-METHYL-PIPERAZINYL)THIAZOL-4-YL]-BENZAMIDE USEFUL AS CYSTEINE PROTEASE INHIBITOR

• Main Authors: Urszula GRABOWSKA, Victor M. DIAZ PEREZ, Andrew CARR, Lourdes SALVADORE-ODEN
• Format: Patent
• Language: English; Spanish
• Published: 26.01.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

There is provided Form 2 crystalline polymorph consisting of N-[1-6-(ethynyl-3-oxo-hexahydro-furo[3,2-b]pyrrole-4-carbonyl)- 3-methyl-butyl]-4-[5-fluoro-2-(4-methyl-piperazin-1-yl)thiazol-4 -yl]-benzamide monohydrochloride and N-[1-6-(ethynyl-3-oxo-hexahydro-furo[3,2-b]pyrrole-4- carbonyl)-3-methyl-butyl]-4-[5-fluoro-2-(4-methyl-piperazin-1-y l)thiazol-4-yl]-benzamide hydrate monohydrochloride, its use as a medicament and methods for its preparation. Se proporciona una forma 2 cristalina polimorfa que consiste de monoclorhidrato de N-[1-6-(etinil-3-oxo-hexahidro-furo[3,2-b]pirro lo-4-carbonil)-3-metil-butil]-4-[5-fluoro-2-(4-metil-piperazin-1- iI)tiazol-4-iI]-enzamida y monoclorhidrato hidrato de N-[1-6-(etinil-3-oxo-hexahidro-furo[3,2-b]pirrolo-4-carbonil)-3-m etil-butil]-4-[5-fluoro-2-(4-metil-piperazin-1-iI)tiazol-4-iI]-be nzamida, su uso como un medicamento y métodos para su preparación.