WHOLE-CELL SYSTEM FOR CYTOCHROME P450 MONOOXYGENASES BIOCATALYSIS

• Main Authors: FRANK HANNEMANN, MICHAEL KLESER, RITA BERNHARDT, ADRIAN GERBER, SABRINA BLEIF
• Format: Patent
• Language: English; Spanish
• Published: 15.04.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The subject of the present invention is a whole-cell catalysis process for converting substrates of cytochrome P450 monooxygenases of eukaryotic origin into valuable biotechnological products. The subject of the present invention is also microorganisms genetically engineered to achieve those biotransformations with high rates and processes to prepare these microorganism strains. El asunto de la presente invención es un proceso de catálisis de células enteras para convertir substratos de monooxigenasas del citocromo P450 de origen eucariótico en productos biotecnológicos valiosos. El asunto de la presente invención es también microorganismos manipulados genéticamente para lograr esas biotransformaciones con regímenes altos y procesos para preparar estas cepas de microorganismos.