PROCESS FOR THE IN SITU SYNTHESIS OF COPPER NANOPARTICLES IN CHITOSAN-POLYVINYL ALCOHOL HYDROGELS AND USE OF THE SAME AS ANTIMICROBIAL AGENT

• Main Authors: CARLOS ALBERTO AVILA ORTA, RUBEN SIERRA AVILA, Roberto Carlos DE LEON PADILLA, GREGORIO CADENAS PLIEGO, Jesus Alejandro ESPINOSA MUÑOZ, HORTENSIA ORTEGA ORTIZ, RAQUEL LEDEZMA RODRIGUEZ
• Format: Patent
• Language: English; Spanish
• Published: 15.06.2017
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRAPPING

The present disclosure is related to a synthesis process of copper nanoparticles (nCu) through the in situ reduction of a copper salt, in the presence of a reducing agent in an aqueous medium with a chitosan-polyvinyl alcohol hydrogel (PVA) to avoid oxidation and agglomeration. The obtained nanoparticles from the present invention correspond to a metallic copper and are uniformly distributed and also have a good chemical stability, a particle size between 20 to 100 nm and hemispheric morphology. Additionally, the nCu present a growth inhibition of 100% against the P. aeruginosa and Staphylococcus aureus bacteria and the Aspergillus niger fungus, so the synthesized nCu can be applied as antimicrobial agents. Se describe un proceso de síntesis de nanopartículas de cobre (nCu) a través de la reducción in situ de una sal de cobre, en presencia de un agente reductor. En un medio acuoso en presencia de un hidrogel de quitosán-polivinil alcohol (PVA) para evitar su oxidación y aglomeración. Las nanopartículas obtenidas en la presente invención corresponden a cobre metálico, están uniformemente distribuidas y presentan una buena estabilidad química, tamaño de partícula entre 20 a 100 nm y morfología semiesférica. Además las nCu presentan una inhibición del crecimiento del 100% contra las bacterias P. aeuroginosa y S. aureus y el hongo A. niger, por lo que las nCu sintetizadas tienen una aplicación como agentes antimicrobianos.