ARTIFICIAL TRANSCRIPTION FACTORS ENGINEERED TO OVERCOME ENDOSOMAL ENTRAPMENT
The invention relates to an artificial transcription factor comprising a polydactyl zinc finger protein targeting specifically a gene promoter, engineered to overcome endosomal entrapment after transduction into cells. Such artificial transcription factor comprises a polydactyl zinc finger protein f...
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Format | Patent |
Language | English Spanish |
Published |
24.06.2016
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Abstract | The invention relates to an artificial transcription factor comprising a polydactyl zinc finger protein targeting specifically a gene promoter, engineered to overcome endosomal entrapment after transduction into cells. Such artificial transcription factor comprises a polydactyl zinc finger protein fused to an inhibitory or activatory protein domain, a nuclear localization sequence, a protein transduction domain, and an endosome-specific protease-recognition site. These transducible artificial transcription factors are particularly useful for the treatment of diseases caused or modulated by membrane-bound receptor proteins, nuclear receptor proteins or products of haploinsufficient genes.
La invención se refiere a un factor de transcripción artificial que comprende una proteína de dedo de zinc polidáctilo que apunta específicamente a un promotor de gen, diseñado para superar a tratamiento endosómico después de transducción dentro de células; tal factor de transcripción artificial comprende una proteína de dedo de zinc polidáctilo fusionada con un dominio de proteína de inhibición o activación, una secuencia de localización nuclear, un dominio de transducción de proteína, y un sitio de reconocimiento de proteasa específico de endosoma; estos factores de transcripción artificiales que se pueden transducir son particularmente útiles para el tratamiento de enfermedades provocadas o moduladas por proteínas de receptor enlazadas a membrana, proteínas de receptor nucleares o productos de genes haploinsuficientes. |
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AbstractList | The invention relates to an artificial transcription factor comprising a polydactyl zinc finger protein targeting specifically a gene promoter, engineered to overcome endosomal entrapment after transduction into cells. Such artificial transcription factor comprises a polydactyl zinc finger protein fused to an inhibitory or activatory protein domain, a nuclear localization sequence, a protein transduction domain, and an endosome-specific protease-recognition site. These transducible artificial transcription factors are particularly useful for the treatment of diseases caused or modulated by membrane-bound receptor proteins, nuclear receptor proteins or products of haploinsufficient genes.
La invención se refiere a un factor de transcripción artificial que comprende una proteína de dedo de zinc polidáctilo que apunta específicamente a un promotor de gen, diseñado para superar a tratamiento endosómico después de transducción dentro de células; tal factor de transcripción artificial comprende una proteína de dedo de zinc polidáctilo fusionada con un dominio de proteína de inhibición o activación, una secuencia de localización nuclear, un dominio de transducción de proteína, y un sitio de reconocimiento de proteasa específico de endosoma; estos factores de transcripción artificiales que se pueden transducir son particularmente útiles para el tratamiento de enfermedades provocadas o moduladas por proteínas de receptor enlazadas a membrana, proteínas de receptor nucleares o productos de genes haploinsuficientes. |
Author | HUXLEY, ALICE FLAMMER, JOSEF NEUTZNER, ALBERT |
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DocumentTitleAlternate | FACTORES DE TRANSCRIPCION ARTIFICIALES DISEÑADOS PARA SUPERAR ATRAPAMIENTO ENDOSOMICO. |
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Snippet | The invention relates to an artificial transcription factor comprising a polydactyl zinc finger protein targeting specifically a gene promoter, engineered to... |
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Title | ARTIFICIAL TRANSCRIPTION FACTORS ENGINEERED TO OVERCOME ENDOSOMAL ENTRAPMENT |
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