COUMARIN DERIVATIVES AND METHODS OF USE IN TREATING HYPERPROLIFERATIVE DISEASES

Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering to a subject a compound as described herein....

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Main Authors JOSEPH P. RITCHIE, ERIC C. SEALES, DEBORAH MAI, HONGWU GAO, JOHN DIXON, ERIK SCHWIEBERT, JOHN STREIFF
Format Patent
LanguageEnglish
Spanish
Published 04.04.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering to a subject a compound as described herein. Also provided are methods for inhibiting the interaction between two or more heat shock protein chaperones in a cell. Se proporcionan compuestos derivados de cumarina y métodos para el tratamiento de enfermedades hiperproliferativas, tales como cáncer, enfermedad renal poliquistica y fibrosis de diferentes tejidos (por ejemplo, fibrosis pulmonar idiopática) Los métodos incluyen administrarle a un sujeto un compuesto tal como se describe en la presente. También se proporcionan métodos para inhibir la interacción entre dos o más proteínas chaperonas de choque térmico en una célula.
Bibliography:Application Number: MX20150013175