3-(ARYL OR HETEROARYL) METHYLENEINDOLIN-2-ONE DERIVATIVES AS INHIBITORS OF CANCER STEM CELL PATHWAY KINASES FOR THE TREATMENT OF CANCER

• Main Authors: WEI LIU, JI-FENG LIU, AMANDA GIBEAU, HARRY ROGOFF, TOSHIO KANAI, KATSUNORI TSUBOL, TOMOHIRO KODAMA, SHINGO TOJO, KATSUMI KUBOTA, YOSUKE TAKANASHI, CHIANG J. LI
• Format: Patent
• Language: English; Spanish
• Published: 31.05.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides compounds of Formula I as inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, wherein i.a. R2 is an optionally substituted heterocycle or optionally substituted aryl; and one of R4, R5, R6and R7 is a substituted heterocycle or substituted aryl. La invención proporciona compuestos de la Fórmula I como inhibidores de las células madre cancerosas así como cinasa de la vía de las células madre cancerosas y otras cinasas relacionadas, composiciones farmacéuticas y usos de las mismas en el tratamiento del cáncer o un trastorno relacionado en un mamífero, en donde R2 es un heterociclo opcionalmente sustituido o arilo opcionalmente sustituido; y una de R4,, R5, R6 Y R7 es un heterociclo sustituido o arilo sustituido.