BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES AND THEIR USE IN THE TREATMENT OF OCULAR VASCULAR DISEASES

The present invention relates to bispecific antibody against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2) of human IgG1 or IgG4 subclass with mutations I253A, H310A, and H435A, methods for their production, pharmaceutical compositions containing sai...

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Main Authors KAY-GUNNAR STUBENRAUCH, CHRISTIAN KLEIN, MATTHIAS RUETH, JOERG THOMAS REGULA, HARALD DUERR, FRANK HERTING
Format Patent
LanguageEnglish
Spanish
Published 23.06.2015
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to bispecific antibody against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2) of human IgG1 or IgG4 subclass with mutations I253A, H310A, and H435A, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. La presente invención se refiere a un anticuerpo biespecífico contra el factor de crecimiento endotelial vascular humano (VEGF/VEGF-A) y contra la angiopoyetina-2 humana (ANG-2) de subclase IgG1 o IgG4 humana con las mutaciones I253A, H310A, y H435A, los métodos para su producción, las composiciones farmacéuticas que contienen tales anticuerpos, y los usos de los mismos.
Bibliography:Application Number: MX20140015518