QUATERNIZED POLYETHYLENIMINES WITH A HIGH QUATERNIZATION DEGREE

• Main Authors: PATRICK DELPLANCKE, MICHAEL STANFORD SHOWELL, RAINER DOBRAWA, SOPHIA EBERT, MARC EVERS, GLORIACAPUA, ANJU BROOKER, MELISSA CUTHBERTSON, PHAN SHEAN LIM, STEFANO SCIALLA, FRANK HUELSKOETTER, GLENN WARD
• Format: Patent
• Language: English; Spanish
• Published: 16.09.2015
• Subjects: ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES; CANDLES; CHEMISTRY; COMPOSITIONS BASED THEREON; DETERGENT COMPOSITIONS; DETERGENTS; FATTY ACIDS THEREFROM; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; RECOVERY OF GLYCEROL; RESIN SOAPS; SOAP OR SOAP-MAKING; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF SINGLE SUBSTANCES AS DETERGENTS

The present invention relates to an ethoxylated polyethylenimine polymer consisting essentially of (a) a polyethyleneimine backbone, (b) a polyoxyethylene chain wherein the polyoxyethylene chain has an average of 1 to less than 40 ethyleneoxide units per unit of NH in the polyethyleneimine backbone, (3) a quaternization degree of from 50% to 100%. The present invention relates to an ethoxylated polyethylenimine polymer consisting essentially of (a) a polyethyleneimine backbone, (b) a polyoxyethylene chain wherein the polyoxyethylene chain has an average of 1 to less than 40 ethyleneoxide units per unit of NH in the polyethyleneimine backbone, (3) a quaternization degree of from 50% to 100%. The present invention relates to manufacturing processes for the preparation of a pharmaceutical dosage form comprising nifedipine and candesartan cilexetil and optionally at least one diuretic characterized in that nifedipine is released in the body in a controlled (modified) manner and the candesartan cilexetil is released rapidly (immediate release (IR)) and optionally the diuretic is released rapidly (immediate release (IR)) and the pharmaceutical dosage forms obtainable by these processes. La presente invención se refiere a un polímero de polietilenimina etoxilada que consiste esencialmente en (a) una estructura de polietilenimina, (b) una cadena de polioxietileno, en donde la cadena de polioxietileno tiene un promedio de 1 a menos de 40 unidades de óxido de etileno por unidad de NH en la estructura de polietilenimina, (3) un grado de cuaternización deI 50% al 100%.