PROSTATE-ASSOCIATED ANTIGENS AND VACCINE-BASED IMMUNOTHERAPY REGIMENS

The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) m...

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Bibliographic Details
Main Authors BRIAN GREGORY PIERCE, JOSEPH JOHN BINDER, VAN TO TSAI, HELEN KIM CHO, JOYCE TSI TAN, MICHAEL ROBERT DERMYER, KARIN UTE JOOSS
Format Patent
LanguageEnglish
Spanish
Published 22.01.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer. La presente invención revela: (a) polipéptidos de PAA inmunógeno aislados; (b) moléculas aisladas de ácido nucleico que codifican péptidos PAA inmunógenos; (c) composiciones de vacuna que comprenden un polipéptido PAA inmunógeno o una molécula aislada de ácido nucleico que codifica un polipéptido PAA inmunógeno; (d) métodos relacionados con usos de los polipéptidos, moléculas de ácido nucleico, y composiciones; y (e) regimenes de inmunoterapia basados en vacunas que implican la coadministración de una vacuna en combinación con un inhibidor de células inmunosupresoras y un reforzador de células inmunoefectoras.
Bibliography:Application Number: MX20140013366