COMPOSITION AND FORMULATION COMPRISING RECOMBINANT HUMAN IDURONATE-2-SULFATASE AND PREPARATION METHOD THEREOF

Disclosed is a composition comprising recombinant iduronate-2-sulfatase (IDS). The glycosylation pattern and formylglycine content of the IDS composition are different from those of Elaprase and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be effective...

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Bibliographic Details
Main Authors YOO CHANG PARK, SANG HOON PAIK, YO KYUNG CHUNG, YONGUL KIM, JINWOOK SEO, YONG WOON CHOI, JONG MUN SON, THONG-GYU JIN
Format Patent
LanguageEnglish
Spanish
Published 11.06.2014
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed is a composition comprising recombinant iduronate-2-sulfatase (IDS). The glycosylation pattern and formylglycine content of the IDS composition are different from those of Elaprase and have superior pharmaceutical efficacy and are safer than the conventional agent and thus can be effectively used for the therapy of Hunter syndrome. Se describe una composición que comprende iduronato-2-sulfatasa (IDS) recombinante. El patrón de glicosilación y contenido de formilglicina de la composición de IDS son diferentes de aquel de Elaprase y tienen eficacia farmacéutica superior y son más seguras que el agente convencional y por lo tanto, puede utilizarse efectivamente para la terapia del síndrome de Hunter.
Bibliography:Application Number: MX20130015127