SUSTAINED RELEASE FORMULATIONS FOR DELIVERY OF PROTEINS TO THE EYE AND METHODS OF PREPARING SAME

• Main Authors: VERNON G. WONG, LOUIS L. WOOD, GLENN T. HUANG
• Format: Patent
• Language: English; Spanish
• Published: 14.05.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to the eye. The formulations are biocompatible, biodegradable sustained release formulations comprising low- solubility liquid excipients and relatively small amounts (less than about 10%) of biocompatible, biodegradable polymer such as PLA or PLGA polymers. A unit dose of 5 μL to 100 μL of the formulation provides for sustained release of the agent for at least 14 days. La presente invención proporciona formulaciones de liberación sostenida farmacéuticas inyectables para el suministro de agentes activos, particularmente proteínas terapéuticas, al ojo. Las formulaciones son formulaciones de liberación sostenida, biocompatibles, biodegradables que comprenden excipientes líquidos de baja solubilidad y cantidades relativamente pequeñas (menos de aproximadamente 10%) de polímero biocompatible, biodegradable tales como polímeros de PLA o PLGA. Una dosis unitaria de 5 µL a 100 µL de la formulación proporciona liberación sostenida del agente durante por lo menos 14 días.