CURCUMINOID SOLID DISPERSION FORMULATION

• Main Authors: KATRIN SCHNEIDER, SHREERAM SATHYA, AI MEY CHUAH, GAURAV C. PATEL, THOMAS K. KESSLER, TAPAS DAS, JOERG BREITENBACH
• Format: Patent
• Language: English; Spanish
• Published: 29.08.2013
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

A curcuminoid formulation, comprising a melt-processed solid dispersion product comprising one or more curcuminoids, a nutritionally acceptable thermoplastic polymer, and a phosphatide; providing an improved oral bioavailability compared to non-formulated crystalline curcuminoid. A method for producing said formulation. A nutritional product fortified with said formulation. Said formulation for use in the treatment or prophylaxis of cancer, conditions involving an inflammatory reaction, neurological disorders, cardiovascular disease, pulmonary disease, the formation of cholesterol gallstones, and parasitic infestation. Una formulación de curcuminoide que comprende un producto de dispersión sólida procesada en estado fundido, que comprende uno o más curcuminoides, un polímero termoplástico aceptable para uso nutricional y un fosfátido; provee una biodisponibilidad oral mejorada en comparación con curcuminoide cristalino no formulado. Un método para producir dicha formulación. Un producto nutricional fortificado con dicha formulación. Dicha formulación para usarse en el tratamiento o profilaxis del cáncer, afecciones que incluyen una reacción inflamatoria, trastornos neurológicos, enfermedad cardiovascular, enfermedad pulmonar, la formación de cálculos biliares de colesterol, e infestación de parásitos.