2-(ARYLAMINO)-3H-IMIDAZO[4,5-B]PYRIDINE-6-CARBOXAMIDE DERIVATIVES AND THEIR USE AS MPGES-1 INHIBITORS

This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M,...

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Main Authors HENNING PRIEPKE, BENJAMIN PELCMAN, ROBERT ROENN, ROLAND PFAU, DIRK STENKAMP, DIMITRIJS LUBRIKS, HENRI DOODS, RAIMUND KUELZER, EDGARS SUNA
Format Patent
LanguageEnglish
Spanish
Published 29.04.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to compounds of formula (I) their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7 have meanings given in the description. Esta invención se refiere a compuestos de fórmula (I)) (ver Fórmula) a su uso como inhibidores de la prostaglandina E2 sintasa-1 microsomal (mPGES-1), a composiciones farmacéuticas que los contienen y a su uso como medicamentos para el tratamiento y/o prevención de enfermedades inflamatorias y afecciones asociadas. A, M, W, R1, R2, R6, R7 tiene los significados dados en la descripción.
Bibliography:Application Number: MX20130001805