METHOD FOR INCREASING THE SENSITIVITY TO INSULIN BY 5-HT2 RECEPTOR ANTAGONISTS

• Main Authors: JUANA MARÍA DE LOURDES MEDINA CONTRERAS, ENRIQUE HONG CHONG
• Format: Patent
• Language: English; Spanish
• Published: 25.04.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention refers to the participation of 5-HT2 serotonergic receptor with an increased insulin sensibility, mainly caused by the peripheral capture of glucose. The present invention is intended to use 5-HT2 receptor antagonist, such as indorrenate (hypertensive agent acting as central 5-HT1A receptor agonist) in pharmaceutical compositions for improving the insulin sensitivity, upon acting as 5-HT2 agonist in the periphery. La presente invención se refiere a la participación de receptores serotonérgicos 5-TH2 con el incremento en la sensibilidad a la insulina, principalmente por aumentar la captura periférica de glucosa. La presente invención tiene como objetivo principal la utilización de agonistas de receptores serotonérgicos 5-HT2, como por ejemplo indorrenato (agente hipertensivo que actúa como agonista de receptores 5-HT1A centrales) en composiciones farmacéuticas para mejorar la sensibilidad a la insulina, al actuar como agonista 5-HT2 en la periferia.