HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN PROTEASE-ACTIVATED RECEPTOR-2

The present invention provides antibodies that bind to protease-activated receptor-2 (PAR-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human PAR-2. The antibodies of the invention are useful, inter alia, for t...

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Bibliographic Details
Main Authors NICHOLAS J. PAPADOPULOS, MICHAEL L. LACCROIX-FRALISH, MARC R. MORRA, ANDREW J. MURPHY, ROBERT R. SALZLER, LYNN MACDONALD
Format Patent
LanguageEnglish
Spanish
Published 03.08.2012
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides antibodies that bind to protease-activated receptor-2 (PAR-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human PAR-2. The antibodies of the invention are useful, inter alia, for the treatment of diseases and disorders associated with one or more PAR- 2 biological activities, including the treatment of pain conditions, inflammatory conditions and gastrointestinal conditions. La presente invención proporciona anticuerpos que unen al receptor- 2 activado por proteasa (PAR-2) y métodos para usar los mismos. De acuerdo a ciertas modalidades de la invención, los anticuerpos son anticuerpos completamente humanos que unen al humano PAR-2. Los anticuerpos de la invención son útiles, entre otras cosas, para el tratamiento de enfermedades o desórdenes asociados con una o mas actividades biológicas de PAR-2, incluyendo el tratamiento de condiciones de dolor, condiciones inflamatorias y condiciones gastrointestinales.
Bibliography:Application Number: MX20120002927