ANTIBODIES CONTAINING THERAPEUTIC TPO/EPO MIMETIC PEPTIDES

• Main Authors: DAVID GIES, JEREMY P. SPRINGHORN
• Format: Patent
• Language: English; Spanish
• Published: 21.09.2011
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The present disclosure features therapeutic antibodies (e.g., TPO mimetic antibodies) and therapeutically-active fragments thereof as well as methods for preparing and using the antibodies and fragments. For example, the therapeutic antibodies and their fragments are useful in a variety of diagnostic and/or therapeutic applications such as methods for increasing platelet levels in a subject. La presente descripción caracteriza anticuerpos terapéuticos (por ejemplo, anticuerpos miméticos TPO) y fragmentos terapéuticamente activos de los mismos así como métodos para preparar y utilizar los anticuerpos y fragmentos. Por ejemplo, los anticuerpos terapéuticos y sus fragmentos son útiles en una variedad de aplicaciones de diagnóstico y/o terapéuticas tales como métodos para aumentar los niveles de plaquetas en un sujeto.