METHOD FOR INHIBITING NEURODEGENERATION

• Main Authors: PINKSTON-GOSSE, JULIE, NIKOLAEV, ANATOLY, TESSIER-LAVIGNE, MARC
• Format: Patent
• Language: English; Spanish
• Published: 28.09.2011
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue. Se presentan métodos para la detección de compuestos que inhiben la neurodegeneración. El desprendimiento de APP puede ser un marcador útil para la neurodegeneración, y los compuestos que inhiben el desprendimiento de APP son útiles como inhibidores de la neurodegeneración. Dichos compuestos pueden ser útiles en el tratamiento y la prevención de diversos trastornos y enfermedades neurológicos, y del daño neuronal, y pueden aumentar el crecimiento, la regeneración o la supervivencia de tejido o células neuronales de mamíferos.