SUBSTRATES PROVIDING MULTIPLE RELEASES OF ACTIVE AGENTS

• Main Authors: DOUGLAS ROBERT HOFFMAN, SARA ANN CARNEY, ANDREA JO SMILTNEEK, JEFFERY RICHARD SEIDLING, SCOTT W. WENZEL, DAVID WILLIAM KOENING
• Format: Patent
• Language: English; Spanish
• Published: 27.06.2011
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; LAYERED PRODUCTS; LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT ORNON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PERFORMING OPERATIONS; PROSTHESES; TRANSPORTING; TREATMENT OR PROTECTION OF EYES OR EARS

The present disclosure comprises a polymeric substrate that provides multiple releases of active agents. A substrate for multiple phase delivery of active agents is provided having a first polymer matrix layer having a first active agent disposed therein, a second polymer matrix layer having a second active agent disposed therein, and a coacervate layer disposed between the first polymer matrix layer and the second polymer matrix layer. Selected first and second active agents are included in the first and second polymer matrices such that as the first and second polymer matrices dissolve, the active agents are released. Multiple phase active agent release is achieved by constructing multiple layers of a polymer matrix containing an active agents formed with polymers having different solubility characteristics or with active agents at different concentration levels. La presente descripción comprende un sustrato polimérico que proporciona liberaciones múltiples de agentes activos. Se proporciona un sustrato para la entrega de fases múltiples de agentes activos teniendo una primera capa de matriz de polímero teniendo un primer agente activo colocado ahí, una segunda capa de matriz de polímero teniendo un segundo agente activo colocado ahí, y una capa de coaservato colocada entre la primera capa de matriz de polímero y la segunda capa de matriz de polímero. Los agentes activos primero y segundo seleccionados son incluidos en las matrices de polímero primera y segunda de manera que al disolverse las matrices de polímero primera y segunda, los agentes activos son liberados. La liberación de agente activo de fases múltiples se logra por la construcción de capas múltiples de una matriz de polímero conteniendo agentes activos formados con polímeros teniendo diferentes características de solubilidad o con agentes activos a diferentes niveles de concentración.