ANTI-IL-12/IL-23 ANTIBODIES

• Main Authors: ANTHONY GERARD DOYLE, LYNN DOROTHY POULTON, PHILIP ANTHONY JENNINGS, ANDREW JAMES POW, ADAM WILLIAM CLARKE, BERNADETTE WAI
• Format: Patent
• Language: English; Spanish
• Published: 29.03.2011
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12R β2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL- 12p80 to human IL-12Rβ1. La presente invención proporciona un anticuerpo que comprende un dominio de enlace de antígeno que enlaza a IL-12 humana e IL-23 humana. El anticuerpo enlaza IL-12p40 humana que existe como un monómero (IL-12p40 humana) y como un homodímero (IL-12p80 humana) y el anticuerpo inhibe el enlace de IL-12 humana a IL-l2Rß2 humana e IL-23 humana a IL-23R humana pero no inhibe el enlace de IL-12 humana o IL-23 humana o IL-12p40 humana o IL-12p80 humana a IL-12Rß1 humana.