SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING β-SECRETASE-INHIBITING ACTIVITY

• Main Authors: YUUJI KOORIYAMA, SAE MATSUMOTO, AKIHIRO HORI, TERUKAZU KATO, SHUJI YONEZAWA, CHIAKI FUJIKOSHI, TATSUHIKO UENO
• Format: Patent
• Language: English; Spanish
• Published: 21.12.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are: a compound represented by formula (I), a pharmaceutically acceptable salt of the compound, or a solvate of the compound or the pharmaceutically acceptable salt thereof; and others, which can be used as therapeutic agents for diseases induced by the production, secretion and/or deposition of amyloid-β protein. [In the formula, the ring A represents a carbocyclic group which may have a substituent, or a heterocyclic group which may have a substituent; R1 represents a lower alkyl which may have a substituent, or the like; R2a and R2b independently represent a hydrogen, a lower alkyl which may have a substituent, or the like; and R3a and R3c independently represent a hydrogen, a halogen, a hydroxy, a lower alkyl which may have a substituent, or the like.]. Se proporciona el siguiente compuesto como un agente para tratar una enfermedad inducida por la producción, secreción y/o depósito de proteína ß-amiloide, por ejemplo, un compuesto representado por la fórmula (I) (ver fórmula (I)) en donde el anillo A es un grupo carbocíclico opcionalmente sustituido o un grupo heterocíclico opcionalmente sustituido, R1 es alquilo inferior opcionalmente sustituido o similares, R2a y R2b son cada uno independientemente hidrógeno, alquilo inferior opcionalmente sustituido o similares, R3a y R3C son cada uno independientemente hidrógeno, halógeno, hidroxi, alquilo inferior opcionalmente sustituido o similares, o una sal farmacéuticamente aceptable, o un solvato del mismo.