PYRROLIDINONE GLUCOKINASE ACTIVATORS

Provided herein are compounds of the formula (I): wherein X, R1, R2 and R3 are as defined in the specification, as well as pharmaceutically acceptable salts thereof. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders...

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Main Authors JEFFERSON WRIGHT TILLEY, RAMAKANTH SARABU, NANCY-ELLEN HAYNES, YIMIN QIAN, LEE APOSTLE MCDERMOTT, STEVEN JOSEPH BERTHEL, ROBERT FRANCIS KESTER, STUART HAYDEN, NATHAN ROBERT SCOTT, JOHN A. BRINKMAN
Format Patent
LanguageEnglish
Spanish
Published 01.11.2010
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds of the formula (I): wherein X, R1, R2 and R3 are as defined in the specification, as well as pharmaceutically acceptable salts thereof. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus. Se proporcionan aquí compuestos de la fórmula (I) (ver fórmula (I)) en la que X, R1, R2 y R3 tienen los significados definidos en la descripción, así como las sales farmacéuticamente aceptables de los mismos. Estos compuestos y las composiciones farmacéuticas que los contienen, son útiles para el tratamiento de enfermedades y trastornos metabólicos por ejemplo, la diabetes mellitus de tipo II.
Bibliography:Application Number: MX20100011226