TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

• Main Authors: TAKAFUMI TAKAI, KATSUMI KOBAYASHI, YASUTAKA HOASHI, KAZUYOSHI ASO, MICHIYO MOCHIZUKI, KAZUYUKI TOKUMARU, TAKUTO KOJIMA
• Format: Patent
• Language: English; Spanish
• Published: 10.08.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

There is provided a compound of the formula (I') : wherein X is a nitrogen or CRx, Rx is a hydrogen, etc., R1 is an optionally substituted hydrocarbon group, etc., R2 is an optionally substituted hydrocarbon group, etc., ring A is 5- to -8-membered heterocyclic ring, etc., and each of Y1,. Y2 and Y3 is an optionally substituted carbon or a nitrogen, etc.; or 'a salt thereof or a prodrug thereof., which have CRF receptor antagonistic activity and use thereof. Se proporciona un compuesto de la fórmula (I'): en donde X es un nitrógeno o CRx, Rx es un hidrógeno, etc., R1 es un grupo de hidrocarburo opcionalmente substituido etc., R2 es un grupo de hidrocarburo opcionalmente substituido, etc., el anillo A es un anillo heterocíclico de 5- a -8-miembros etc., y cada uno de Y1,. Y2 e Y3 es un carbono opcionalmente substituido o un nitrógeno, etc.; o una sal del mismo o un profármaco del mismo, que tiene actividad antagonista del receptor CRF y proporciona también el uso del mismo.