ANTI-HUMAN IL-21 MONOCLONAL ANTIBODIES

Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeut...

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Main Authors MARK W. RIXON, EUGENE C. YI, CECILE M. KREJSA, STEPHEN R. JASPERS, STACEY R. DILLON, FREDERICK J. RAMSDELL
Format Patent
LanguageEnglish
Spanish
Published 01.07.2010
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells TH cells or TH17 cells. Se presentan anticuerpos humanos monoclonales IL-21 anti-humanos y los hibridomas que los producen. Ciertos de estos anticuerpos tienen la capacidad para enlazar IL-21 humano nativo, una proteína IL-21 recombinante de mutante y/o regiones de péptido de IL-21 humano. Estos anticuerpos anti-IL-21 humanos son útiles en tratamiento terapéutico de enfermedades autoinmunitarias e inflamatorias, particularmente enfermedades mediadas por células auxiliares foliculares T, células TH de células B o células TH17.
Bibliography:Application Number: MX20100006181