ARYL-SUBSTITUTED BRIDGED OR FUSED DIAMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE

• Main Authors: EDWARDS, JAMES, P, MCCLURE, KELLY, J, LANDRY-BAYLE, ANDRIENNE, M, GOMEZ, LAURENT, ECCLES, WENDY, BEMBENEK, SCOTT, D, MIRZADEGAN, TARANEH, GRICE, CHERYL, A, LEE-DUTRA, ALICE, BACANI, GENESIS, M, EPPERSON, MATTHEW, T, SANTILLAN, ALEJANDRO, JR, KEARNEY, AARON, M
• Format: Patent
• Language: English; Spanish
• Published: 27.05.2010
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction. Compuestos de diamina puenteados o fusionados sustituidos con arilo, composiciones farmacéuticas que los contienen y métodos de usar los compuestos y las composiciones farmacéuticas para la modulación de leucotrieno A4 hidrolasa (LTA4H o LTA4H) y para el tratamiento de los estados de enfermedad, trastornos y afecciones mediadas por la actividad de la LTA4H, tales como la alergia, asma, enfermedades autoinmunes, pruritis, enfermedad inflamatoria intestinal, colitis ulcerativa y enfermedad cardiovascular, incluso aterosclerosis y prevención del infarto del miocardio.