PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF

• Main Authors: YUN HE, BAOGEN WU, NATHANAEL S. GRAY, GUOBAO ZHANG, XING WANG, TAEBO SIM, YONGPING XIE, TRUC NGOC NGUYEN
• Format: Patent
• Language: English; Spanish
• Published: 01.02.2010
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of AIk, AbI, Aurora- A, B-Raf, C- Raf, Bcr-Abl, BRK, BIk, Bmx, BTK, C-Kit, C-Raf, C-Src, EphB1, EphB2, EphB4, FGFR1, FGFR2, FGFR3, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRalpha, PDGFRbeta, PKCalpha, p38, Src, SIK, Syk, Tie2 and TrkB kinases. La invención proporciona compuestos y composiciones farmacéuticas de los mismos, los cuales son útiles como inhibidores de la cinasa de proteína, y métodos para utilizar tales compuestos con el fin de tratar, aminorar, o prevenir una condición asociada con una actividad anormal o mal regulada de la cinasa. En algunas modalidades, la invención proporciona métodos para utilizar estos compuestos con el fin de tratar, aminorar, o prevenir enfermedades o trastornos que involucren una activación anormal de las cinasas Alk, AbI, Aurora-A, B-Raf, C-Raf, Bcr-Abl, BRK, Blk, Bmx, BTK, C-Kit, C-Raf, C-Src, EphB1, EphB2, EphB4, FGFR1, FGFR2, FGFR3, FLT1, Fms, Flt3, Fyn, FRK3, JAK2, KDR, Lck, Lyn, PDGFRa, PDGFRß, PKCa, p38, Src, SIK, Syk, Tie2 y TrkB.