PHENYL AMINO PYRIMIDINE COMPOUNDS AND USES THEREOF

The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inf...

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Bibliographic Details
Main Authors CHRISTOPHER JOHN BURNS, THAO LIEN THI NGYGEN, JUN ZENG, ANDREW FREDERICK WILKS, JOHN THOMAS FEUTRILL, ANDREW CRAIG DONOHUE
Format Patent
LanguageEnglish
Spanish
Published 23.09.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases. La presente invención se relaciona a compuestos de fenil amino pirimidina que son inhibidores de proteína quinasas que incluyen quinasas de JAK. En particular los compuestos son selectivos para las quinasas de JAK2. Los inhibidores de quinasa se pueden utilizar en el tratamiento de enfermedades asociadas con quinasa tales como enfermedades inmunológicas e inflamatorias que incluyen transplantes de órganos; enfermedades hiperproliferativas que incluyen cáncer y enfermedades mieloproliferativas; enfermedades virales; enfermedades metabólicas; y enfermedades vasculares.
Bibliography:Application Number: MX20090009792