SUBSTITUTED TETRACYCLINE COMPOUNDS

The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms. La presente invención pertenece, al menos en parte, a un comp...

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Main Authors LAURA HONEYMAN, JOEL BERNIAC, OAK K. KIM, TODD BOWSER, BEENA BHATIA, PAUL ABATO, JINGWEN PAN, ATUL VERMA, MARK NELSON, MARK GRIER, HAREGEWEIN ASSEFA, MOHAMED ISMAIL
Format Patent
LanguageEnglish
Spanish
Published 20.08.2009
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms. La presente invención pertenece, al menos en parte, a un compuesto tetraciclina sustituida que tiene la fórmula (I): en donde X es CHC(R13VY), CR6 R6, C=CR6, S, NR6 u O; E es NR7dR7?, OR7f ó (CH2)o.iC(=W)WR7s; W es O, S, NR711 ó CR75R7*; W es O, S ó NR7*; estos compuestos tetaciclina pueden utilizarse para tratar numerosos estados sensibles a los compuestos tetraciclina, como pueden ser infecciones bacterianas y neoplasmas.
Bibliography:Application Number: MX20090006846