ANTIMICROBIAL LINEAR PEPTIDES

• Main Authors: RAFAEL FERRE MALAGON, EDUARD BARDAJI RODRIGUEZ, LIDIA FELIU SOLEY, MARTA PLANAS GRABULEDA, EMILI MONTESINOS SEGUI, ESTHER BADOSA ROMACHO
• Format: Patent
• Language: English; Spanish
• Published: 07.01.2009
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

The present invention relates to novel linear peptides with antimicrobial activity. Said peptides are made up of 11 amino acids, and they have the amino group of the amino acid constituting the N-terminal end in a non-derived form or functionalized with an acetyl group, p-toluene sulphonyl, benzyl or benzoyl. The amino acid constituting the C-terminal end of said peptides is in carboxamide form. The invention describes the synthesis and use of said peptides as antimicrobial agents to combat pathogenic bacteria for plants. The invention also relates to compositions containing said peptides and an auxiliary agent, and to a method for preventing and treating infections and diseases of plants caused by pathogenic bacteria. La presente invención se refiere a nuevos péptidos lineales que presentan actividad antimicrobiana. Dichos péptidos están formados por 11 aminoácidos, y tienen el grupo amino del aminoácido que constituye el extremo N-terminal sin derivatizar o funcionalizado con el grupo acetilo, p-toluensulfonilo, bencilo o benzoílo. El aminoácido que constituye el extremo C-terminal de dichos péptidos está en forma de carboxamida. La invención describe la síntesis y la utilización de los mencionados péptidos como agentes antimicrobianos frente a bacterias patógenas para plantas. También se refiere a composiciones que comprenden dichos péptidos y un agente auxiliar, y a un método para prevenir y tratar infecciones y enfermedades de plantas causadas por bacterias patógenas.