SYNTHETIC PEPTIDES USED FOR TREATING THE SKIN AND USE THEREOF IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS

• Main Authors: JOAN CEBRAIN PUCHE, ARTURO PUIG MONTIEL, CRISTINA CARRENO SERRAIMA, ELENA PASSERINI, WILL VAN DEN NEST, NURIA ALMINANA DOMENECH
• Format: Patent
• Language: English; Spanish
• Published: 06.03.2009
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

The present invention relates to peptides of general formula (I) that are capable of regulating fibrillogenesis, stereoisomers thereof and mixtures thereof, which may or may not be racemic, and the cosmetically or dermopharmaceutically acceptable salts thereof, in which Z is alanyl, allo-isoleucyl, glycyl, isoleucyl, isoseryl, isovalyl, leucyl, norleucyl, norvalyl, prolyl, seryl, threonyl, allo-threonyl or valyl; n and m may vary between 1 and 5; AA is selected from the group formed by natural amino acids encoded in their L- or D- form and non-encoded amino acids; x and y may vary between 0 and 2; R1 is H or an alkyl, aryl, aralkyl or acyl group; and R2 is amino, hydroxyl or thiol, all these possibly being substituted with aliphatic or cyclic groups. A method for obtaining cosmetic or dermopharmaceutical compositions containing them and use thereof for treating the skin, preferably those skin conditions that require the regulation of fibrillogenesis, such as aging and/or the softening of the appearance of scars. La presente invención se refiere a péptidos de fórmula general (I) capaces de regular la fibrilogénesis, sus estereoisómeros y mezclas de los mismos, racémicas o no, y las sales cosméticamente o dermofarmacéuticamente aceptables de los mismos, en donde Z es alanil allo-isoleucil, glicil, isoleucil, isoseril, isovalil, leucil, norleucil, norvalil, prolil, seril, treonil, allo-treonil o valil; n y m pueden variar entre 1 y 5; AA se selecciona del grupo formado por los aminoácidos naturales codificados en su forma L- o D- y aminoácidos no codificados; x e y pueden variar entre 0 y 2; R1 es H o grupo alquilo, arilo, aralquilo o acilo; y R2 es amino, hidroxilo o tiol, todos ellos sustituidos o no con grupos alifáticos o cíclicos. Un método de obtención, composiciones cosméticas o dermofarmacéuticas que los contienen y su uso para tratar la piel, preferentemente aquellas condiciones de la piel que requieran regular la fibrilogénesis como son el envejecimiento y/o suavización de la apariencia de las cicatrices. (ver fórmula I).