CHEMOKINE RECEPTOR BINDING COMPOUNDS

• Main Authors: ZHOU, YUANXI, LI, TONG-SHUANG, METZ, MARKUS, BRIDGER, GARY J, BOURQUE, ELYSE, MCEACHERN, ERNEST J, SKERLJ, RENATO T, ZHU, YONGBAO, HARWING, CURTIS
• Format: Patent
• Language: English; Spanish
• Published: 27.11.2008
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV). La presente invencion se refiere a compuestos de unión al receptor de quimiocina, a composiciones farmacéuticas y a su uso; más específicamente, la presente invención se refiere a moduladores de la actividad del receptor de quimiocina, preferiblemente moduladores de CCR4 o CCR5; en un aspecto, estos compuestos demuestran efectos protectores contra la infección de células de objetivo mediante un virus de inmunodeficiencia humana (VIH).