NOVEL SALTS OF CONJUGATED PSYCHOTROPIC DRUGS AND PROCESSES OF PREPARING SAME

• Main Authors: ABRAHAM WEIZMAN, IRIT GIL-AD, SHLOMIT HALACHMI, ERAN J. BENJAMIN, ABRAHAM NUDELMAN, ADA REPHAELI
• Format: Patent
• Language: English; Spanish
• Published: 06.03.2008
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Novel chemical conjugates of a psychotropic drug residue and an amino-containing organic acid residue selected to reduce side effects induced by the psychotropic drug when administered per se, to enhance the therapeutic activity of the psychotropic drug and/or to exert anti-proliferative activity, in which the amino group is in the form of an acid addition salt thereof and which are characterized by high stability are disclosed. Further disclosed are processes for preparing the chemical conjugates and addition salts thereof, pharmaceutical compositions containing the chemical conjugates and methods utilizing the chemical conjugates for treating various medical conditions. Se divulgan conjugados quimicos novedosos de un residuo de farmaco sicotropico y un residuo de acido organico que contiene amino seleccionado para reducir los efectos secundarios inducidos por el farmaco sicotropico cuando se administra per se, para aumentar la actividad terapeutica del farmaco sicotropico y/o para ejerce actividad antiproliferativa, en los cuales el grupo amino esta en la forma de una sal de adicion del acido del mismo y que se caracterizan por alta estabilidad. Ademas se divulgan procesos para preparar los conjugados quimicos y sales de adicion de los mismos, composiciones farmaceuticas que contienen los conjugados quimicos y metodos que utilizan los conjugados quimicos para tratar varias condiciones medicas.