COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING FLAVIVIRIDAE INFECTIONS

• Main Authors: DUGOURD, DOMINIQUE, RUBINCHIK, EVELINA, CLEMENT, JACOB, FRIEDLAND, HILLEL, DAVID
• Format: Patent
• Language: English; Spanish
• Published: 14.01.2008
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates generally to compositions having a glucosidase inhibitor (castanospermine or a derivative thereof, such as celgosivir) in combination with adjunctive therapies of compounds that alter immune function (such as interferon) and compounds that alter viral replication (such as nucleoside analogues like ribavirin), which can be used to treat or prevent infections caused by or associated with a virus of the Flaviviridae family, particularly infections caused by or associated with Hepatitis C virus (HCV). La presente descripcion se refiere en general a composiciones que tienen un inhibidor de glucosidasa (castanospermina o uno de sus derivados, tal como celgosivir) en combinacion con terapias auxiliares de compuestos que alteran la funcion inmune (tal como interferona) y compuesto que alteran la replicacion viral (tales como analogos nucleosido como ribavirina), que pueden emplearse para tratar o evitar infecciones provocadas por o asociadas con un virus de la familia Flaviviridae, particularmente infecciones provocadas por o asociadas con virus de Hepatitis C (HCV = Hepatitis C virus).