NOVEL INJECTABLE WIDE SPECTRUM ANTIBACTERIAL FORMULATION FOR BOVINE CATTLE

The present invention refers to a novel veterinary antibacterial formulation of modified release. The combination of doxycycline, ß-Cyclodextrin and Poloxamer 407 of the inventive formulation avoids pain and reduces local irritation in parenteral application, also increasing the active stability and...

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Bibliographic Details
Main Authors HECTOR SALVADOR SUMANO LOPEZ, LILIA GUTIERREZ OLVERA, DINORAH VARGAS ESTRADA
Format Patent
LanguageEnglish
Spanish
Published 25.02.2009
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention refers to a novel veterinary antibacterial formulation of modified release. The combination of doxycycline, ß-Cyclodextrin and Poloxamer 407 of the inventive formulation avoids pain and reduces local irritation in parenteral application, also increasing the active stability and achieving a slow active release. The formulation is recommended to be parenterally applied to bovine cattle (ruminants) since it does not affect micro flora and micro fauna present in their pre-stomach, which is useful for using fibre-rich (cellulose) food so as to absorb, as final products, volatile fatty acids and microbial proteins having a higher quality than that of vegetable proteins; the metabolism of nitrogen and vitamins of group B are further synthesized by microbial fermentation in the digestive tract. La presente invención se refiere a una nueva formulación antibacterial veterinaria de liberación modificada. La combinación de doxiciclina, ß-Ciclodextrina y Poloxámero 407 de la formulación de la invención, evita el dolor y reduce la irritación local a la aplicación parenteral además de incrementar la estabilidad del activo y logra una liberación lenta del activo. Se recomienda la aplicación por vía parenteral para el ganado bovino (rumiantes) debido a que no afecta la microflora y microfauna existente en su pre-estómago útil para el aprovechamiento de alimentos ricos en fibras (celulosa), absorbiendo como productos finales ácidos grasos volátiles y proteínas microbianas de calidad superior a la vegetal; además, el metabolismo del nitrógeno y las vitaminas del grupo B se sintetizan mediante fermentación microbiana en el tracto digestivo.
Bibliography:Application Number: MX20070005000