APTAMERS TO VON WILLEBRAND FACTOR AND THEIR USE AS THROMBOTIC DISEASE THERAPEUTICS

• Main Authors: DIENER, JOHN, L, LAGASSE, DANIEL, H., A
• Format: Patent
• Language: English; Spanish
• Published: 05.03.2008
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnositcs of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor. La invencion se relaciona generalmente con el campo de los acidos nucleicos y mas particularmente con aptameros capaces de unirse al Factor de von Willebrand, utiles como agentes terapeuticos y de diagnostico de las enfermedades tromboticas y/u otras enfermedades o trastornos en los cuales se ha implicado la agregacion de las plaquetas mediada por el Factor de von Willebrand. La invencion se relaciona ademas con materiales y metodos para la administracion de aptameros capaces de unirse al Factor de von Willebrand.