IMIDAZOLO-RELATED COMPOUNDS, COMPOSITIONS AND METHODS FOR THEIR USE

• Main Authors: JASON A. DUQUETTE, DARIN GUSTIN, XIAOHUI DU, JEFFREY T. MIHALIC, MICHAEL G. JOHNSON, PHILIPPE BERGERON, JULIO C. MEDINA, JEFFREY DEIGNAN, XIAOQI CHEN, ANDREW P. MARCUS, ZICE FU, AN-RONG LI
• Format: Patent
• Language: English; Spanish
• Published: 11.05.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds are provided having the formual (I) wherein variables R0,R1, R2, R3, R4, Q, L and subscript n areas described herein. The subject compounds are useful for treatment of infammatoryand immune conditions and diseases. Compositions and methods of treatment usingthe subject compounds are also provided. For example, the subject methods areuseful for treatment of inflammatory and immune disorders and disease such asmultiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory boweldisease. Se proporcionan compuestos que tienen la formula () en donde las variables RD, R, R, R3, R4, Q, L y el subindice n son como se describen en la presente. Los compuestos objetos son utiles para el tratamiento de condiciones y enfermedades inflamatorias e inmunes. Las composiciones y metodo de tratamiento que utilizan los compuestos objeto tambien se proporcionan. Por ejemplo, los metodos objetos son utiles para el tratamiento de trastornos y enfermedades inflamatorias e inmunes tales como esclerosis multiple, artritis reumatoide, psoriasis, y enfermedad del intestino inflamatoria.