TETRAHYDROQUINAZOLIN-4(3H)-ONE-RELATED AND TETRAHYDROPYRIDO[2,3-D ]PYRIMIDIN-4(3H)-ONE-RELATED COMPOUNDS, COMPOSITIONS AND METHODS FOR THEIR USE

• Main Authors: JASON A. DUQUETTE, DARIN GUSTIN, XIAOHUI DU, JEFFREY T. MIHALIC, MICHAEL G. JOHNSON, PHILIPPE BERGERON, JULIO C. MEDINA, XIAOQI CHEN, JEFFREY DEIGNAN, ANDREW P. MARCUS, ZICE FU, AN-RONG LI
• Format: Patent
• Language: English; Spanish
• Published: 11.05.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds are provided having the formula (I) wherein variables A1, A2,A3, A4, R1, R2, R3, R4,Q and L are described herein. The subject compounds are useful for treatment ofinflammatory and immune conditions and diseases. Compositions and methodsof treatment using the subject compounds are also provided. For example, thesubject methods are useful for treatment of inflammatory and immune disorders anddisease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatorybowel disease. Se proporcionan compuestos que tienen la formula (:) en donde las variables A', A', A, A4, R', R', R', R4, Q L se describen en la presente. Los compuestos objeto son utiles para el tratamiento de enfermedades y condiciones inflamatorias e inmune. Las composiciones y metodos de tratamiento que utilizan los compuestos objetos son tambien proporcionados. Por ejemplo, los metodos objetos son utiles para el tratamiento de trastornos y enfermedades inflamatorias e inmunes tal como esclerosis multiple, artritis reurnatoide, psoriasis, y enfermedad del intestino inflamatorio.