USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO

• Main Authors: CHU, ZHI-LIANG, JONES, ROBERT M, LEONARD, JAMES N, LEHMANN, JUERG
• Format: Patent
• Language: Bosnian; English
• Published: 10.10.2010
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Predstavljeni pronalazak se odnosi na primjenu agonista GRP119 receptora za liječenje ili prevenciju stanja koje karakteriše niska koštana masa, kao što je osteoporoza, i za povećanje koštane mase kod jedinki. Predstavljeni pronalazak se dalje odnosi na primjenu agonista GPR119 receptora u konbinaciji sa inhibitorom dipepti dil pepti daze IV (DPP-IV) za liječenje i prevenciju stanja koje karakteriše niska koštana masa, kao što je osteoporoza, i za povećanje koštane mase kod jedinki. Agonist GPR119 receptora i inhibitora DPP-IV sti mulišu formiranje kosti kod jedinki. The present invention relates to the use of GPR119 receptor agonists for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. The present invention further relates to the use of a GPR119 receptor agonist in combination with a dipeptidyl peptidase IV (DPP-IV) inhibitor for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. A GPR119 receptor agonist and the combination of a GPR119 receptor agonist and a DPP-IV inhibitor promote bone formation in an individual.