DIMETHOXY DOCETAXEL ACETONE SOLVATE ET METHOD FOR THE PREPARATION THEREOF

Pronalazak se odnosi na acetonske derivate dimetoksi docetaksela ili 4-acetoksi-2a-benzoiloksi-5p,20-epoksi-1 -hidroksi-7p,1 OP-dimetoksi-9-oksotaks-1 I -en-13 α -i I (2R.3S)-3-terc-butoksikarbonilamino-2-hidroksi-3-fenilpropionata i na njihovo dobijanje kristalizacijom iz hidro-acetonskog rastvora....

Full description

Saved in:
Bibliographic Details
Main Authors DIDIER, ERIC, PERRIN, MARC-ANTOINE
Format Patent
LanguageBosnian
English
Published 10.06.2010
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:Pronalazak se odnosi na acetonske derivate dimetoksi docetaksela ili 4-acetoksi-2a-benzoiloksi-5p,20-epoksi-1 -hidroksi-7p,1 OP-dimetoksi-9-oksotaks-1 I -en-13 α -i I (2R.3S)-3-terc-butoksikarbonilamino-2-hidroksi-3-fenilpropionata i na njihovo dobijanje kristalizacijom iz hidro-acetonskog rastvora. The acetone solvate (A) of 4-acetoxy-2alpha -benzoyloxy-5beta ,20-epoxy-1-hydroxy-7beta ,10beta -dimethoxy-9-oxo-tax-11-en-13alpha -yl (2R,3S)-3-tert. butoxycarbonylamino-2-hydroxy-3-phenylpropionate (I) (i.e. dimethoxy docetaxel) (preferably containing 5-7 wt. % acetone) is new. An independent claim is included for the preparation of (A). ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given in the source material.
Bibliography:Application Number: ME2008P000117