DEUTERATED I SOINDOLINE- I, 3-DIONE DERIVATIVES AS PDE4 AND TNF-ALPHA INHIBITORS

This invention relates to novel substituted isoindoline-1,3-dione derivatives' of formula Ia and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast. This invention also provi...

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Bibliographic Details
Main Author LIU, Julie, F
Format Patent
LanguageEnglish
Published 20.12.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to novel substituted isoindoline-1,3-dione derivatives' of formula Ia and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast. This invention also provides compositions comprising a compound of this invention and a carrier and the use of disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering apremilast.
Bibliography:Application Number: MEP5914