FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS

• Main Authors: FOLEY, Anne Marie, AUJLA, Pavandeep Singh, FRANKLIN, Richard Jeremy, ALEXANDER, Rikki Peter, CRÉPY, Karen Viviane Lucile
• Format: Patent
• Language: English
• Published: 20.09.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Serije   derivata  6,7-di hidro [1,3] tia zolo[5,4-c] piridin -4(5H)-on,  i njihovi  analo zi ,  koji su supstituisani na poziciji  2  sa ponekad supstituisanim ostatkom   morfolin -4- il ,  a koji su selektivni  inhibitor i   encima  PI3 kina za ,  pokazuju potencijalnu medicinsku korist ,  na   primer   u   tretman u poremećaja zapaljenja,  auto - imun og ,  k ardiovas k ular n ih , neurodegenerativ n ih , metaboli čk ih , on k olo šk ih , nociceptiv n ih  ili  o f talm ičkih  poremećaja . A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.