(THIO) CARBAMOYL-CYCLOHEXANE DERIVATIVES AS D3/D2 RECEPTOR ANTAGONISTS

• Main Authors: VAGO, ISTVAN, AGAINE CSONGOR, EVA, KISS, BELA, LASZY, JUDIT, LASZLOVSZKY, ISTVAN, SAGHY, KATALIN, GALAMBOS, JANOS, GYERTYAN, ISTVAN, NOGRADI, KATALIN
• Format: Patent
• Language: Croatian; English
• Published: 20.12.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Predstavljeni pronalazak se odnosi na nove ligande za podgrupu D2 i D3 dopaminskih receptora formule (I): gdje R1 i R2 nezavisno predstavljaju supsti tuent izabran iz grupe koju čine vodonik, alkil, aril, cikloalkil, aroil, ili R1 i R2 mogu da formiraju heterocikličan prsten sa susjednim atomom azota; X predstavlja atom kiseonika ili sumpora; n je cio broj od 1 do 2; i/ili njihove geometrijske izomere i/ili stereoizomere i/ili diastereomere i/ili soli i/ili hidrate i/ili solvate, na postupak za njihovu proizvodnju, farmaceutske kompozicije koje ih sadrže i na njihovu primjenu u liječenju i/ili prevencijui stanja koje zahti jeva modulaciju dopaminskih receptora. The present invention relates to new D3 and D2 dopamine receptor subtype preferring ligands of formula (I): wherein R1 and R2 represent independently a substituent selected from hydrogen, alkyl, aryl, cycloalkyl, aroyl, or R1 and R2 may form a heterocyclic ring with the adjacent nitrogen atom; X represents an oxygen or sulphur atom; n is an integer of from 1 to 2, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates thereof, to the processes for producing the same, to pharmaceutical compositions containing the same and to their use in therapy and/or prevention of a condition which requires modulation of dopamine receptors.